Laboratory Personnel
Graduate Courses:
Fundamentals of Bioinformatics 6640
and
Advanced Bioinformatics 8630
Useful Links
Crystal Structures
Research Projects
We are studying the molecular basis of disease by analyzing the mode of action
of key regulatory proteins at the molecular level
using the techniques of bioinformatics, biochemistry and
crystallography.
- Retroviral Proteases:
HIV and other retroviruses cause AIDS
and cancer in humans and other animals. We are
studying the crystal structures and enzyme activties of
drug resistant mutants of HIV protease and developing new
antiviral inhibitors.
- Caspases:
Caspases regulate apoptosis and inflammation by cleavage of
proteins. Abnormal caspase activity is associated with many
diseases: cancer, neurodegenerative diseases, stroke, heart
disease, sepsis, viral and bacterial infections. We are
studying the structure and substrate recognition of caspases.
- Est30
The crystal structure of thermostable carboxyesterase Est30 has a covalent
reaction intermediate. This active site geometry is relevant for many
enzymes in the serine hydrolase superfamily.
- Glucokinase and glycemic diseases:
Molecular models of human glucokinase have been used to understand the
effects of mutations associated with diabetes and other glycemic diseases.
- Molecular Modeling Methods:
Protein structures are being predicted by
Homology Modeling using AMMP.