HIV and other retroviruses cause AIDS
and cancer in humans and other animals. We are
studying the crystal structures and enzyme activities of
drug resistant mutants of HIV protease and developing new
Summary of recent results
Caspases regulate apoptosis and inflammation by cleavage of
proteins. Abnormal caspase activity is associated with many
diseases: cancer, neurodegenerative diseases, stroke, heart
disease, sepsis, viral and bacterial infections. We are
studying the structure and substrate recognition of caspases
with applications in the control of cancer and Alzheimer's disease.
Bacterial enzymes are targets for design of antibiotics. We are studying the
structures of various enzymes including choline oxidase, D-amino acid dehydrogenases, esterases and superoxide dismutases.
Glucokinase and glycemic diseases:
Molecular models of human glucokinase have been used to understand the
effects of mutations associated with diabetes and other glycemic diseases.
Molecular Modeling Methods: Protein structures are being predicted by Homology Modeling using AMMP.